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admin Posts: 30	There are too much tabs today. The world pharma industry works in full force. New names & brends occur each new season and even pharmaceutists seldom are confused a lot. So, we decided to make HOT MEDS list, mostly it contains the USA best buy products as the USA is the world pharma market leader. Top-10 drugs in the United States 01. Lipitor remedy to reduce cholesterol levels Sales in 2006 : $6600000 000 International name : Atorvastatin Indications for use. Reducing cholesterol is almost a national primary idea of America. Not surprisingly, most drugs sold in the United States (and the world) are aimed at achieving this goal. In general, it is correct: elevated cholesterol attaches the vascular wall, forms atheromatous plaque and leads to atherosclerosis, which causes up to 40% of deaths. The volume of market is also impressive. Annual sales in the United States are approximately equal to the annual sales of all drugs manufactured in Russia. The drugs act. Atorvastatin which hides under the brand name Lipitor, is the representative of a large class of statins. These drugs reduce the enzyme activity, which is involved in the synthesis of cholesterol in the liver cells. Statins were found in the early 70-s by Japanese Akira Endo, who was looking for new antibiotics. Although his invention did not bring Mr. Endo even a cent: all the money were given to big corporations like Merck and Pfizer, and each of them have developed its synthetic statins. Side effects. As the tastiest piece of medical cake, Atorvastatin is always attacked from all sides. It is clamed that it causes muscle pain, impotence, depression and problems with the liver. But the worst thing is that, according to some data it can increase in 12 times more the risk of having breast cancer 02. Nexium remedy from heartburn Sales in 2006 : $4000000 000 International name : Ezomeprazol The drugs act. The curing substance is ezomeprazol which is blocking so-called proton pump that creates acid environment in the stomach. This reduces the danger of getting acid in the gullet (this causes heartburn), and cures ulceration. Buying conditions. At first AstraZeneca started selling omeprazol. In the beginning it was sold under the brand Losec, but the federal agency for drugs (FDA) told the company to change the name to avoid confusion with the diuretic Lasix. AstraZeneca renamed omeprazol in Prilosec, but still it appears to be a bad idea : due to the bad handwriting of doctors customers started to mix this draug with the the antidepressant Prozac. However by this time the patent of AstraZeneca has expired, and the similar drugs of other manufactures has appeared on the market. The next events are the classic examples of corporation struggle for the prolongation of the monopoly on the drug sale. AstraZeneca released Nexium to the market, which is ezomeprazol, chemically it is the same as omeprazol, but it consists only of a single optical isomer. Optical isomers are identical molecules that are the mirror reflections of each other. Omeprazol consisted of the "left" and "right" molecule, while ezomeprazol has only "left". AstraZeneca proved that they have healing features, that’s why it was granted a new patent, related only to this form. 03. Prevacid remedy from heartburn Sales in 2006 : $3300000 000 International name : Lansoprazol Indications for use. It turns out that heartburn is a serious problem for always nervous Americans. Mechanism of action and chemical structure of the drug is very similar to Nexium. Although Prevacid is slightly less efficient, it can be easily used together with other drugs. In Russia there are many analogues of this drug. The most famous one is drug manufactured in Obolensk called "Epicure" in honor to the founder of the philosophy of pleasure, including gastronomic one. 04. Advair Diskus remedy against asthma Sales in 2006: $3100000 000 The international title: Salmeterol + Flonase Form of release. The best seller drug against asthma on American market mostly is not the achievement of science but mechanics. The drug Advair (in Europe, including Russia- seretid) is a combination of two well-known substances for inhalation in the form of powder: flutikazon and salmeterol. However, the form of package-a small streamline device the use of which is difficult to define is perhaps the most bright expression of the desire of producers to make treatment not only easy but also enjoyable. The Powder is packed in doses between the two tapes of foil, and as caps are charged in a special inhaler. Before each use it is necessary to cock lever, which punches a dose, and then inject the powder through a nozzle. Each tape is enough for 60 doses, so the asthmatic can charge it only once in a month. Side effects. A small "but": In 2005, FDA issued a warning that in rare cases, the salmeterol can leads to sudden death from asthma attack. 05. Singulair Remedy against allergy Sales in 2006: $2500000 000 International name: Montelukast The drugs act. The drug is designed to deal with the symptoms of allergies and asthma prevention. There is a new mechanism which is different from steroids and antihistamine remedies . Montelukast is associated with leykotrien receptors, signal molecules that are involved in the processes of inflammation and allergic responses. As a result, the system of leykotrien signal stops working and the patient feels better. In Russia montelukast is presented solely as a legal product of a Merck company. 06. Effexor XR Antidepressant Sales in 2006: $2300000 000 International name: Venlafaksin Pharmacological group. The rank of the main antidepressant in the most concerned on mental health nation of the world is a guarantee of getting into the annals of not only medical but also pop culture, especially taking into account that the majority of this pop culture are on antidepressants. Instead of the Prozac which was famous in the 80-s a new leading drug called effexor (the same as Venlafaxin) appeared at the market Side effects. Like other antidepressants, venlafaksin has lots of disadvantages and side effects. End of taking this drug has the worst of all drugs in this group elimination syndrome during which the risk of suicide increases in 2-3 times. After an incident, in 2001, when the woman that was taking this drug has drowned her five children, the company Wyeth placed in the list of possible complications a rare item "an impulse to kill people", however, it placed it only on the 36th page of the instruction. Form of release. Letters XR in the title refer to the drug in slow motion. After taking one pill a day, an active ingredient is absorbed by body slowly, which reduces the undesirable effects and extends the therapeutic effect. In Russia effexor XR is not sold, but the usual venlafaxin is available in three versions - from Croatia, Hungary and Iceland. 07. Plavix Remedy against trombus Sales in 2006: $2200000 000 International name: Klopidogrel Interaction with other drugs. Previously plavix wason the second place after lipitor, but in 2006 he was the target of an attack of analogue drugs made by Canadian manufacturer Apotex. It all started in early spring : Apotex said it believed the patent of Bristol-Squibb and its partner Sanofi-Aventis is invalid and therefore it will begin to sell not branded klopidogrel immediately. The owners of the patent went to the court, but then they came to an amicable agreement : Apotex received 40 million dollars, and the right to start selling the analogue eight months earlier the date of expiration of the patent in 2011, but it should refuse from its plans annul the patent. This would the end of the case, but the antimonopoly committee had not approved the deal. Then was found out that smart Canadians included in the contract so many reservations that now they can begin to sell their products without fear of too large fines. Throughout the month, while owners of patents were busy at the courts, they had shipped so much cheap drugs that the rates of original Plavix was reduced almost in two times. 08. Zocor Remedy to reduce level of cholesterol Sales in 2006: $2170000 000 The international title: Simvastatin Pharmacological group. Zokor is a product of the same class of statins as lipitor, and it reduces cholesterol with the help of the same mechanism. Specific instructions. Zokor was the first widely used statin in medicine, but now its best days are behind and sales are declining. Corporation Merck put it on the market several years earlier than Pfizer-lipitor, so that the patent protection on it has expired in 2006. IAhuge amount of similar drugs appeared on the market, but Merck has made the unusual step and has reduced the price of zokor to the level of new products. So the holder of the brand itself has issued a cheap analogue, and has left competitors with nothing. 09. Norvasc Means to reduce pressure Sales in 2006: $2150000 000 International name Amlodipin The drugs act. Norvasc is the most up to date representative of the digidropiridin group used in cardiology since 70s . This medicine is used to treat high pressure and coronary heart disease. They block calcium pumps in the cells, expanding vessels and thereby lowering resistance to blood flow. The acting part of norvasc is amlodipin. It influences the vessels 80 times more than heart tissue, and therefore it doesn't harm heart muscle . Interaction with other drugs. The company Pfizer which is producing norvasc will lose its right on monopolistic sale in September 2007 however it is preparing for this event with usual ingenuity. It began to sell kaduet drug ,which is a combination of two popular drugs for heart sufferers (lipitor and norvasc). Due to the fact that together they form a new drug it require a new patent protection. Meanwhile Russia is selling more than a dozen of cheap analogues of amlodipin. 10. Lexapro Antidepressant Sales in 2006: $2100000 000 International name: Estsitalopram Form of release. The history of estsitalopram begins in 1989, with the inventition of citalopram. This antidepressant was very successful and has yielded a huge revenue to its producer, the company Forest Laboratories. In 2003, the patent has expired, and the company has developed and patented estsitalopram, which is in fact one of the two optical isomers of tsitalopram. In Russia it is possible to buy now both tsitalopram analogues, and licensed estsitalopram, which is two to three times more expensive. Time to make money on rx-drugs with an industry leader! Seopharmacy.com